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gt protein (fruit fly) - STRING interaction network
"gt" - Giant in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gtGiant; Represses the expression of both the krueppel and knirps segmentation gap genes. Binds, in vitro, to the krueppel regulatory elements CD1 and CD2. It is required in the early embryo for the development of portions of the head and abdomen (448 aa)    
Predicted Functional Partners:
tor
Torso; Probable receptor with tyrosine-protein kinase activity. Required for determination of anterior and posterior terminal structures in the Drosophila embryo. The ligand of torso seems to be TSL (923 aa)
       
 
  0.735
slbo
Slow border cells; May be required for the expression of gene products mediating border cell migration. Among the DNA sequences that this protein binds with high affinity is a conserved site within the promoter of its gene (449 aa)
       
  0.647
Max
Max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (161 aa)
       
  0.462
brm
Brahma; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (1658 aa)
       
    0.431
CG15400
Glucose-6-phosphatase activity (350 aa)
         
  0.414
Jra
Jun-related antigen; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’ (PubMed-1696724, PubMed-2116361). Plays a role in dorsal closure (PubMed-9224723) (372 aa)
     
  0.404
Rbf2
Retinoblastoma-family protein 2 (783 aa)
     
    0.400
Rbf
Retinoblastoma-family protein; Functions in cell cycle regulation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site- specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes (845 aa)
     
    0.400
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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