STRINGSTRING
eIF2B-beta protein (fruit fly) - STRING interaction network
eIF2B-beta in Drosophila melanogaster
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eIF2B-betaeIF2B-beta (352 aa)    
Predicted Functional Partners:
CG3806
eIF2B-epsilon (669 aa)
     
  0.998
CG8190
eIF2B-gamma (455 aa)
     
  0.998
CG7883
eIF2B-alpha (306 aa)
   
0.997
CG10315
eIF2B-delta (626 aa)
     
0.997
eIF-2alpha
Translation initiation factor activity; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region (341 aa)
     
  0.993
eIF-2beta
Eukaryotic initiation factor 2beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region (312 aa)
     
  0.992
eIF-2gamma
GTP binding; GTPase activity; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity) (475 aa)
     
  0.986
Kap-alpha3
Protein binding (514 aa)
     
      0.887
Es2
Es2 (501 aa)
     
      0.885
CG11334
Translation regulator activity; Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) (364 aa)
   
 
  0.867
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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