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CG2652 protein (fruit fly) - STRING interaction network
"CG2652" - GH07966p in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CG2652GH07966p; It is involved in the biological process described with- regulation of transcription, DNA-templated (235 aa)    
Predicted Functional Partners:
DMAP1
DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses. Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel. Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling (433 aa)
     
 
  0.855
TfIIFalpha
General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation; Belongs to the TFIIF alpha subunit family (577 aa)
     
 
  0.820
bip2
Bip2; P53 binding; protein binding; zinc ion binding; POZ domain binding; transcription factor binding; chromatin binding. It is involved in the biological process described with- positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter (1406 aa)
     
 
  0.798
Bap55
Brahma associated protein 55kD; Transcription coactivator activity. It is involved in the biological process described with- mitotic nuclear division; muscle organ development; chromatin remodeling; mitotic cytokinesis; positive regulation of transcription, DNA-templated; dendrite guidance; DNA repair; dendrite morphogenesis; positive regulation of gene silencing by miRNA; Belongs to the actin family (425 aa)
     
 
  0.774
TfIIFbeta
General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity (By similarity) (277 aa)
     
 
  0.735
Taf13
TBP-associated factor 13; Protein heterodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly. It is involved in the biological process described with- transcription initiation from RNA polymerase II promoter (136 aa)
     
 
  0.723
Taf1
Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp; Belongs to the TAF1 family (2172 aa)
     
 
  0.713
E(Pc)
Enhancer of polycomb-like protein; It is involved in the biological process described with- dendrite guidance; chromatin organization (2023 aa)
     
 
  0.669
rept
RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (481 aa)
     
 
  0.667
YL-1
Vacuolar protein sorting-associated protein 72 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV (351 aa)
       
 
  0.647
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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