STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cibEG:EG0007.11 protein; Ciboulot (cib) encodes an actin binding protein involved in brain development and the remodeling of the larval central nervous system. (129 aa)    
Predicted Functional Partners:
chic
Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance.
   
 
 0.765
Act5C
Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
   
 
 0.651
MSBP
Membrane steroid binding protein, isoform A; Ecdysone binding; Belongs to the cytochrome b5 family.
   
  
 0.566
chb
CLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...]
      
 0.533
eIF1A
Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition.
   
  
 0.531
KP78a
LP21052p1; Protein serine/threonine kinase activity; ATP binding; tau-protein kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; microtubule cytoskeleton organization.
      
 0.530
CG3860
Oxysterol-binding protein; Lipid binding; sterol binding; sterol transporter activity; Belongs to the OSBP family.
      
 0.491
CG15099
Protein dopey-1 homolog; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family.
   
  
 0.479
Sh3beta
SH3 domain-binding glutamic acid-rich protein homolog.
   
 
 0.471
CG13386
Uncharacterized protein.
      
 0.459
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.