STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHOp24CHOp24, isoform A; CHOp24 (CHOp24) encodes a p24 transporter that contributes to the intracellular trafficking between the ER and Golgi. It is required for secretion of Wnt ligands. (208 aa)    
Predicted Functional Partners:
bai
Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected; Belongs to the EMP24/GP25L family.
   
0.996
p24-2
P24-related-2, isoform A; P24-related-2 (p24-2) encodes a p24-transporter-type protein involved in post-mating oviposition.
   
0.978
p24-1
P24-related-1, isoform A; P24-related-1 (p24-1) encodes a p24 protein that contributes to the secretion of Wnt ligands.
   
0.954
eca
Transmembrane emp24 domain-containing protein eca; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected. Involved in Golgi organization. Belongs to the EMP24/GP25L family.
   
0.947
Sec23
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
   
 
 0.862
Surf4
Surfeit locus protein 4 homolog; Belongs to the SURF4 family.
   
 0.811
Sec22
Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family.
   
 0.764
C901
RT07140p1; Notch binding. It is involved in the biological process described with: cell communication.
     
  0.750
wry
Weary, isoform B; Weary (wry) encodes a ligand for the receptor encoded by N. It is involved in the Notch signaling pathway and normal heart function.
     
  0.750
Bet1
Blocked early in transport 1, isoform A; SNAP receptor activity; syntaxin binding. It is involved in the biological process described with: vesicle fusion with Golgi apparatus; vesicle-mediated transport; protein transport; endoplasmic reticulum to Golgi vesicle-mediated transport.
   
 
 0.706
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.