Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome.

Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...]

FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination.

E3 ubiquitin-protein ligase Topors; Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effec [...]

Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 20/33 (Usp20-33) encodes a deubiquitinase involved in nervous system development.

Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins.

Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

Ubiquitin carboxyl-terminal hydrolase puf; Ubiquitin hydrolase that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Essential for Myc-mediated cell growth and proliferation in developing eyes and wings. In the wing and eye, the deubiquitinating activity acts as an antagonist to the SCF E3 ubiquitin-protein ligase member archipelago (ago) to regulate Myc and CycE stability and thus control cell growth and proliferation. Also appears to regulate ago by modulating its induction by Myc. May also promote cell apoptosis in the wing imaginal disk, acting in an a [...]

Deubiquitinating apoptotic inhibitor, isoform A; Cysteine-type endopeptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; negative regulation of apoptotic process; negative regulation of proteolysis involved in cellular protein catabolic process; ubiquitin-dependent protein catabolic process.