node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MBD-R2 | Rcd1 | FBpp0082081 | FBpp0302789 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | 0.999 |
MBD-R2 | Rcd5 | FBpp0082081 | FBpp0073058 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. | 0.999 |
MBD-R2 | dgt1 | FBpp0082081 | FBpp0308967 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. | 0.996 |
MBD-R2 | mle | FBpp0082081 | FBpp0085367 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.958 |
MBD-R2 | mof | FBpp0082081 | FBpp0070794 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Males-absent on the first protein; Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positivel [...] | 0.990 |
MBD-R2 | msl-1 | FBpp0082081 | FBpp0080674 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. | 0.965 |
MBD-R2 | msl-2 | FBpp0082081 | FBpp0077260 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. | 0.907 |
MBD-R2 | msl-3 | FBpp0082081 | FBpp0076635 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable. | 0.980 |
MBD-R2 | nsl1 | FBpp0082081 | FBpp0301595 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Non-specific lethal 1, isoform M; Non-specific lethal 1 (nsl1) encodes a H4 histone acetyltransferase involved in muscle development, oogenesis and regulation of endocytosis. | 0.987 |
MBD-R2 | wds | FBpp0082081 | FBpp0300790 | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.994 |
Rcd1 | MBD-R2 | FBpp0302789 | FBpp0082081 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | 0.999 |
Rcd1 | Rcd5 | FBpp0302789 | FBpp0073058 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Reduction in Cnn dots 5 (Rcd5) encodes a protein that belongs to the family of forkhead-associated domain proteins. As part of the non-specific lethal complex, it regulates transcription of housekeeping genes by facilitating recruitment of RNA polymerase II to promoters. During mitosis it plays a key role in chromosomal-dependent microtubule assembly, centriole duplication and pericentriolar material maturation. | 0.999 |
Rcd1 | dgt1 | FBpp0302789 | FBpp0308967 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Dim gamma-tubulin 1, isoform C; Histone acetyltransferase activity (H4-K16 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific). It is involved in the biological process described with: histone H4-K16 acetylation; histone H4-K8 acetylation; histone H4-K5 acetylation. | 0.999 |
Rcd1 | mle | FBpp0302789 | FBpp0085367 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.947 |
Rcd1 | mof | FBpp0302789 | FBpp0070794 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Males-absent on the first protein; Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positivel [...] | 0.991 |
Rcd1 | msl-1 | FBpp0302789 | FBpp0080674 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Protein male-specific lethal-1; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. | 0.961 |
Rcd1 | msl-2 | FBpp0302789 | FBpp0077260 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. | 0.921 |
Rcd1 | msl-3 | FBpp0302789 | FBpp0076635 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Protein male-specific lethal-3; Male-specific lethal 3 (msl-3) encodes a chromodomain protein, reported to interact with H3K36me3, H4K20me1 and DNA. It is a member of the Male-Specific-Lethal dosage compensation complex, which increases male X chromosome transcription approximately two-fold. Homozygous mutant males die as larvae, while females are viable. | 0.957 |
Rcd1 | nsl1 | FBpp0302789 | FBpp0301595 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Non-specific lethal 1, isoform M; Non-specific lethal 1 (nsl1) encodes a H4 histone acetyltransferase involved in muscle development, oogenesis and regulation of endocytosis. | 0.990 |
Rcd1 | wds | FBpp0302789 | FBpp0300790 | Reduction in Cnn dots 1 (Rcd1) encodes a protein involved in centriole replication and transcription regulation. | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. | 0.997 |