node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG14207 | Hsf | FBpp0074503 | FBpp0110266 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | 0.551 |
CG14207 | Hsp22 | FBpp0074503 | FBpp0100010 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | 0.508 |
CG14207 | MAPk-Ak2 | FBpp0074503 | FBpp0292066 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.895 |
CG14561 | MAPk-Ak2 | FBpp0306231 | FBpp0292066 | UT01525p. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.745 |
CrebB | MAPk-Ak2 | FBpp0402805 | FBpp0292066 | Cyclic AMP response element-binding protein B; Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory ; Belongs to the bZIP family. ATF subfamily. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.789 |
Erk7 | MAPk-Ak2 | FBpp0071264 | FBpp0292066 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.803 |
Hsf | CG14207 | FBpp0110266 | FBpp0074503 | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | 0.551 |
Hsf | Hsp22 | FBpp0110266 | FBpp0100010 | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | 0.703 |
Hsf | MAPk-Ak2 | FBpp0110266 | FBpp0292066 | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.777 |
Hsf | p38a | FBpp0110266 | FBpp0083966 | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | P38a MAP kinase (p38a) encodes a member of the mitogen-activated protein kinases responsive to diverse stresses. In immune response, it activates its downstream component encoded by Atf-2 that in turn regulates Duox expression. | 0.402 |
Hsf | p38b | FBpp0110266 | FBpp0080111 | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. | 0.404 |
Hsp22 | CG14207 | FBpp0100010 | FBpp0074503 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | 0.508 |
Hsp22 | Hsf | FBpp0100010 | FBpp0110266 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | 0.703 |
Hsp22 | MAPk-Ak2 | FBpp0100010 | FBpp0292066 | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.735 |
MAPk-Ak2 | CG14207 | FBpp0292066 | FBpp0074503 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | 0.895 |
MAPk-Ak2 | CG14561 | FBpp0292066 | FBpp0306231 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | UT01525p. | 0.745 |
MAPk-Ak2 | CrebB | FBpp0292066 | FBpp0402805 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Cyclic AMP response element-binding protein B; Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory ; Belongs to the bZIP family. ATF subfamily. | 0.789 |
MAPk-Ak2 | Erk7 | FBpp0292066 | FBpp0071264 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. | 0.803 |
MAPk-Ak2 | Hsf | FBpp0292066 | FBpp0110266 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | 0.777 |
MAPk-Ak2 | Hsp22 | FBpp0292066 | FBpp0100010 | MAP kinase-activated protein kinase 2; Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Heat shock protein 22 (Hsp22) encodes a molecular chaperone that is encoded in the nucleus and targeted to the mitochondrial matrix. Hsp22 expression is dramatically increased during aging, and both Hsp22 mutation and over-expression are reported to modulate adult life span and stress resistance. | 0.735 |