STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EfrUDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (352 aa)    
Predicted Functional Partners:
nac
GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Plays a major role in the fucosylation of N-glycans. Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling; Belongs to the TPT transporter family. SLC35C subfamily.
   
  
 0.904
frc
UDP-sugar transporter UST74c; Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35D subfamily.
   
  
 0.904
AMPdeam
AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
 
 
    0.900
sll
Slalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
   
  
 0.897
senju
UDP-galactose transporter senju; UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz.
      
 0.710
tws
Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
 
    
 0.689
CG9826
Uncharacterized protein, isoform A; Transmembrane transporter activity. It is involved in the biological process described with: anion transport; transmembrane transport.
      
 0.680
CG31229
Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
      
 0.672
mey
Morpheyus, isoform A; It is involved in the biological process described with: apical constriction; regulation of embryonic cell shape.
      
 0.602
Gmer
Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
      
 0.533
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.