node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYPT-75D | Mbs | FBpp0303838 | FBpp0300535 | MYPT-75D, isoform A; Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | 0.433 |
MYPT-75D | Pp1-87B | FBpp0303838 | FBpp0082067 | MYPT-75D, isoform A; Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. | Serine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.675 |
MYPT-75D | flw | FBpp0303838 | FBpp0071381 | MYPT-75D, isoform A; Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. | Serine/threonine-protein phosphatase beta isoform; Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development. Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.993 |
MYPT-75D | sqh | FBpp0303838 | FBpp0308587 | MYPT-75D, isoform A; Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. | Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. | 0.958 |
Mbs | MYPT-75D | FBpp0300535 | FBpp0303838 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | MYPT-75D, isoform A; Myosin phosphatase targeting subunit 75D (MYPT-75D) encodes a protein phosphatase 1 binding protein involved in myosin phosphatase regulation. | 0.433 |
Mbs | Mlc-c | FBpp0300535 | FBpp0300803 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | 0.741 |
Mbs | Pp1-87B | FBpp0300535 | FBpp0082067 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Serine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.962 |
Mbs | Rac1 | FBpp0300535 | FBpp0304252 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | 0.679 |
Mbs | Rho1 | FBpp0300535 | FBpp0086354 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | 0.862 |
Mbs | Rok | FBpp0300535 | FBpp0074061 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. | 0.864 |
Mbs | flw | FBpp0300535 | FBpp0071381 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Serine/threonine-protein phosphatase beta isoform; Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development. Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.993 |
Mbs | sqh | FBpp0300535 | FBpp0308587 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. | 0.949 |
Mbs | zip | FBpp0300535 | FBpp0072306 | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | Myosin heavy chain, non-muscle; Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment. Interaction with the myosin ck may be important for this function. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.798 |
Mlc-c | Mbs | FBpp0300803 | FBpp0300535 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Myosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. | 0.741 |
Mlc-c | Mlc1 | FBpp0300803 | FBpp0310544 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Myosin light chain alkali; Microfilament motor activity; calcium ion binding. It is involved in the biological process described with: muscle contraction; mesoderm development. | 0.789 |
Mlc-c | Pp1-87B | FBpp0300803 | FBpp0082067 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Serine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.738 |
Mlc-c | Rac1 | FBpp0300803 | FBpp0304252 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | 0.630 |
Mlc-c | Rho1 | FBpp0300803 | FBpp0086354 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | 0.671 |
Mlc-c | Rok | FBpp0300803 | FBpp0074061 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Rho-associated protein kinase; Rho kinase (Rok) encodes a kinase that, when activated by the GTP form of the product of Rho1, phosphorylates and modulates cytoskeletal proteins, particularly myosin II. Dynamic regulation of this kinase in subcellular locales influences cell polarization, movement, and shape during interphase and mitosis. | 0.531 |
Mlc-c | flw | FBpp0300803 | FBpp0071381 | Myosin light chain cytoplasmic (Mlc-c) encodes a subunit of the myosin complex that is involved in actin filament-based movement. | Serine/threonine-protein phosphatase beta isoform; Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development. Belongs to the PPP phosphatase family. PP-1 subfamily. | 0.647 |