STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mab-21Protein mab-21; Belongs to the mab-21 family. (365 aa)    
Predicted Functional Partners:
Sting
Sting, isoform B; cyclic-di-GMP binding; cyclic-GMP-AMP binding.
    
 
 0.687
path
Proton-coupled amino acid transporter-like protein pathetic; Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline. Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway. Required in a cell- autonomous manner for dendrite growth in neurons with large dendrite arbors.
      
 0.666
Chpf
Hexosyltransferase; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity.
      
 0.635
SmydA-8
SET domain-containing protein SmydA-8, isoform A; Histone deacetylase binding; S-adenosylmethionine-dependent methyltransferase activity. It is involved in the biological process described with: histone lysine methylation; negative regulation of gene expression.
      
 0.601
CG4975
Uncharacterized protein, isoform C.
      
 0.589
Best4
Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family.
  
     0.447
Muc12Ea
Mucin 12Ea; Extracellular matrix structural constituent. It is involved in the biological process described with: chorion-containing eggshell formation.
      
 0.440
CG3062
Protein Flattop homolog; It is involved in the biological process described with: cilium organization; Belongs to the Flattop family.
      
 0.438
Best3
Bestrophin 3 (Best3) encodes a paralog of the product of Best1, a Ca-activated Cl channel. A C-terminal domain inhibits the Cl channel function so that the product of Best3 does not produce current at physiological transmembrane voltages; Belongs to the bestrophin family.
  
     0.435
rg
Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body. Belongs to the WD repeat neurobeachin family.
 
 
  
 0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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