node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG2224 | CG3781 | FBpp0303776 | FBpp0070860 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Josephin-like protein; May act as a deubiquitinating enzyme. | 0.713 |
CG2224 | RpL40 | FBpp0303776 | FBpp0306837 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.935 |
CG2224 | RpS27A | FBpp0303776 | FBpp0079606 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.933 |
CG2224 | Rpn8 | FBpp0303776 | FBpp0303270 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | 26S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. | 0.528 |
CG2224 | Ubi-p5E | FBpp0303776 | FBpp0311816 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. | 0.877 |
CG2224 | Uch-L5 | FBpp0303776 | FBpp0076200 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. | 0.825 |
CG2224 | Usp14 | FBpp0303776 | FBpp0304059 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 14 (Usp14) encodes a deubiquitinase that associates with the 19S component of the proteasome in a reversible manner. Its functions include ubiquitin chain disassemblance for mono-ubiquitin recycling, control of protein degradation by the proteasome and regulation of proteasome subtrate interactions. | 0.784 |
CG2224 | Usp7 | FBpp0303776 | FBpp0073474 | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. | 0.715 |
CG3781 | CG2224 | FBpp0070860 | FBpp0303776 | Josephin-like protein; May act as a deubiquitinating enzyme. | FI19924p1; Thiol-dependent ubiquitin-specific protease activity; Lys63-specific deubiquitinase activity. It is involved in the biological process described with: protein deubiquitination; protein K63-linked deubiquitination. | 0.713 |
CG3781 | Rad23 | FBpp0070860 | FBpp0305835 | Josephin-like protein; May act as a deubiquitinating enzyme. | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | 0.729 |
CG3781 | RpL40 | FBpp0070860 | FBpp0306837 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.826 |
CG3781 | RpS27A | FBpp0070860 | FBpp0079606 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.842 |
CG3781 | Rpn8 | FBpp0070860 | FBpp0303270 | Josephin-like protein; May act as a deubiquitinating enzyme. | 26S proteasome non-ATPase regulatory subunit 7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family. | 0.664 |
CG3781 | Ubi-p5E | FBpp0070860 | FBpp0311816 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. | 0.734 |
CG3781 | Uch-L5 | FBpp0070860 | FBpp0076200 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. | 0.670 |
CG3781 | Usp14 | FBpp0070860 | FBpp0304059 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 14 (Usp14) encodes a deubiquitinase that associates with the 19S component of the proteasome in a reversible manner. Its functions include ubiquitin chain disassemblance for mono-ubiquitin recycling, control of protein degradation by the proteasome and regulation of proteasome subtrate interactions. | 0.746 |
CG3781 | Usp7 | FBpp0070860 | FBpp0073474 | Josephin-like protein; May act as a deubiquitinating enzyme. | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. | 0.768 |
CG3781 | smt3 | FBpp0070860 | FBpp0078984 | Josephin-like protein; May act as a deubiquitinating enzyme. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.784 |
Rad23 | CG3781 | FBpp0305835 | FBpp0070860 | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | Josephin-like protein; May act as a deubiquitinating enzyme. | 0.729 |
Rad23 | RpL40 | FBpp0305835 | FBpp0306837 | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.952 |