STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sniSniffer, isoform A; Sniffer (sni) encodes a homodimeric carbonyl reductase that belongs to the SDR superfamily of proteins. It catalyzes the reduction of the lipid derived aldehyde 4-oxononenal. It contributes to protection against oxidative stress-induced neurodegeneration and prevention of apoptosis by removal of damaged cardiolipin; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)    
Predicted Functional Partners:
sws
Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family.
      
 0.790
Sws1
SWIM domain containing Srs2 interacting protein 1 (Sws1) encodes a protein that is paralog-interacting of the product of spn-A. It is involved in homologous recombination in the repair of double-strand breaks, likely through the product of spn-A regulation.
      
 0.668
Tmem18
Transmembrane protein 18.
      
 0.531
Mnn1
Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like.
      
 0.525
Cyp305a1
Probable cytochrome P450 305a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
   
  
 0.516
Ugt37A3
UDP-glycosyltransferase family 37 member A3; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity.
   
  
 0.497
Cyp6d2
Cyp6d2 (Cyp6d2) encodes a member of the cytochrome P450 oxidase protein family and is involved in the detoxification of toxic compounds. Two common Cyp6d2 alleles found in many Dmel stocks result in extreme sensitivity to camptothecin.
   
  
 0.457
Cyp309a1
Probable cytochrome P450 309a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
   
  
 0.451
Wwox
WW domain containing oxidoreductase (Wwox) encodes a protein that contributes to homeostasis by regulating the balance between oxidative phosphorylation and glycolysis. It modulates the cell death mediated by the product of egr, which is accompanied by an increase in levels of reactive oxygen species; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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