node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG4972 | Crag | FBpp0079578 | FBpp0310013 | Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.530 |
Cam | Crag | FBpp0293502 | FBpp0310013 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.582 |
Cam | Rab11 | FBpp0293502 | FBpp0083413 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. | 0.453 |
Crag | CG4972 | FBpp0310013 | FBpp0079578 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family. | 0.530 |
Crag | Cam | FBpp0310013 | FBpp0293502 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. | 0.582 |
Crag | Evi5 | FBpp0310013 | FBpp0073392 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. | 0.631 |
Crag | Fbxl4 | FBpp0310013 | FBpp0073740 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | 0.608 |
Crag | Pak | FBpp0310013 | FBpp0306609 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. | 0.535 |
Crag | Rab10 | FBpp0310013 | FBpp0077029 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. | 0.785 |
Crag | Rab11 | FBpp0310013 | FBpp0083413 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. | 0.704 |
Crag | Rbcn-3B | FBpp0310013 | FBpp0310568 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Rabconnectin-3B, isoform A; Rabconnectin-3B (Rbcn-3B) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells. | 0.554 |
Crag | vimar | FBpp0310013 | FBpp0085514 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Visceral mesodermal armadillo-repeats (vimar) encodes a protein involved in regulation of muscle homeostasis and rhabdomere development. Its expression in the visceral mesoderm is controlled by the product of bap. | 0.604 |
Crag | wus | FBpp0310013 | FBpp0309739 | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | Wurst, isoform A; Wurst (wus) encodes a transmembrane protein essential for clathrin-mediated endocytosis. It recruits the product of Hsc70-4 and clathrin to the apical cell membrane of epithelial cells. The endocytosis mediated by the product of wus is required for size determination and lumen clearance of the airways. | 0.610 |
Evi5 | Crag | FBpp0073392 | FBpp0310013 | Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.631 |
Evi5 | Rab10 | FBpp0073392 | FBpp0077029 | Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. | LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. | 0.522 |
Evi5 | Rab11 | FBpp0073392 | FBpp0083413 | Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge. | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. | 0.792 |
Fbxl4 | Crag | FBpp0073740 | FBpp0310013 | F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.608 |
Fbxl4 | vimar | FBpp0073740 | FBpp0085514 | F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | Visceral mesodermal armadillo-repeats (vimar) encodes a protein involved in regulation of muscle homeostasis and rhabdomere development. Its expression in the visceral mesoderm is controlled by the product of bap. | 0.600 |
Pak | Crag | FBpp0306609 | FBpp0310013 | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.535 |
Rab10 | Crag | FBpp0077029 | FBpp0310013 | LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. | DENN domain-containing protein Crag; Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11. Essential for maintenance of adult photoreceptor cells. Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells. Functions by targeting Rab10 [...] | 0.785 |