STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIP82PIP82; It is involved in the biological process described with: cellular response to light stimulus. (1195 aa)    
Predicted Functional Partners:
gl
Glass (gl) encodes a zinc finger transcription factor involved in cell fate specification. It is primarily transcribed in photoreceptors, where its expression is activated by the retinal determination member encoded by so. gl is required for correctly patterning the retina, rhabdomere formation, and for the expression of phototransduction proteins.
   
 
 0.845
Pph13
PvuII-PstI homology 13 (Pph13) encodes a paired-class homeodomain protein. It is critical for rhabdomeric photoreceptor differentiation, phototransduction and rhabdomere morphogenesis.
   
 
 0.707
eys
Protein eyes shut; Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system.
   
 
 0.614
CG43218
MIP12702p; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
 
 0.530
Gbeta76C
Guanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit.
   
 
 0.512
CG13375
EG:BACR37P7.8 protein; GDP binding; GTPase activity; GTP binding. It is involved in the biological process described with: signal transduction.
    
 
 0.507
CG14589
Uncharacterized protein, isoform C.
    
 
 0.498
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
   
 
 0.498
CG3603
RH09070p; Estradiol 17-beta-dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; 3-hydroxyacyl-CoA dehydrogenase activity; quinone binding. It is involved in the biological process described with: oxidation-reduction process; fatty acid biosynthetic process.
    
 
 0.495
CG12912
IP05237p.
      
 0.493
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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