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Atg8a protein (fruit fly) - STRING interaction network
"Atg8a" - Autophagy-related 8a in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Atg8aAutophagy-related 8a (Atg8a) is a ubiquitin-like protein that is conjugated to phosphatidylethanolamine, and this lipid modification anchors it into the membrane of forming and completed autophagosomes. Atg8a roles include autophagosome formation, maintaining neuromuscular function and normal lifespan (121 aa)    
Predicted Functional Partners:
Atg7
Autophagy-related 7 is an E1-type ligase for the autophagic ubiquitin-like proteins Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan (684 aa)
     
  0.999
Atg3
Autophagy-related protein 3; Small conjugating protein ligase activity; Atg8 ligase activity. It is involved in the biological process described with- autophagy (330 aa)
     
  0.999
Atg4a
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy (411 aa)
     
  0.999
Atg5
Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity) (269 aa)
     
  0.999
Atg6
Beclin-1-like protein; Autophagy-related 6 is a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis (422 aa)
     
  0.999
Atg12
Autophagy protein 12-like; Required for autophagy (111 aa)
     
  0.999
Pi3K59F
Phosphotidylinositol 3 kinase 59F, also known as Vacuolar protein sorting 34, is a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes Atg6 and Vps15 and is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis; Belongs to the PI3/PI4-kinase family (949 aa)
       
  0.998
Atg18a
Autophagy-related 18a regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes (447 aa)
     
  0.997
Atg18b
Autophagy-related 18b, isoform A; Phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with- cellular response to oxidative stress; autophagic vacuole assembly (471 aa)
     
  0.997
Atg4b
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy (668 aa)
     
  0.996
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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