STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CG9754Protein panoramix; Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts. Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (541 aa)    
Predicted Functional Partners:
arx
Gametocyte-specific factor 1 homolog; Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for repression of transposons and neighboring genes in ovarian somatic and germline cells
   
  
 0.832
nxf2
Nuclear RNA export factor 2; May be involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family
   
 
 0.748
piwi
Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael- dependent manner. [...]
   
 
 0.726
zuc
Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...]
   
  
 0.712
wde
Windei, isoform A; Windei
   
  
 0.697
vret
Protein vreteno; Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues
   
  
 0.677
krimp
FI20010p1; Metal ion binding. It is involved in the biological process described with: karyosome formation; oocyte dorsal/ventral axis specification; negative regulation of oskar mRNA translation
   
  
 0.672
Gasz
Gasz is an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface
   
  
 0.663
SoYb
Sister of Yb is a putative RNA helicase in the TDRD12 family. It has an essential role in primary piRNA biogenesis in ovarian somatic cells and is predicted to also have a role in germline piRNA biogenesis
   
  
 0.620
tlk
Tousled-like kinase, isoform G; Protein kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; regulation of cell shape; mitotic cell cycle, embryonic; regulation of cell cycle; protein autophosphorylation; antimicrobial humoral response; histone phosphorylation; chromosome segregation; cell adhesion; chromatin organization
    
   0.611
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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