STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HmgDHigh mobility group protein D; Binds preferentially single-stranded DNA and unwinds double- stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1. (112 aa)    
Predicted Functional Partners:
His1:CG31617
Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
   
 
 0.826
Df31
Decondensation factor 31 (Df31) encodes a histone binding protein involved in nucleosome assembly.
   
  
 0.688
His2Av
Histone H2A.v; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repre [...]
   
 
 0.688
Nacalpha
Nascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes (By similarity). Required for correct localization of the osk/oskar protein to the posterior pole during embryonic development. The osk protein directs the recruitment of molecules responsible for posterior body patterning and germline formation in the embryo.
   
 
 0.682
Hmg-2
High mobility group protein 2 (Hmg-2) encodes a member of the non-histone chromosomal high-mobility group protein family. These proteins associate with with chromatin and are ubiquitously distributed in the nucleus of eukaryotic cells. The product of Hmg-2 binds to DNA in a non-sequence specific fashion to induce structural changes in DNA that include bending and unwinding that in turn, promote DNA flexibility.
   
  
 0.613
HemK2
HemK methyltransferase 2; Protein methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity; nucleic acid binding. It is involved in the biological process described with: methylation.
   
 
 0.612
CG8321
LD43023p.
    
 
 0.610
CG42697
Uncharacterized protein.
      
 0.609
His1:CG33807
Histone H1; Nucleosomal DNA binding; double-stranded DNA binding; chromatin DNA binding.
   
 
 0.568
His1:CG33834
Histone H1; Double-stranded DNA binding; chromatin DNA binding; nucleosomal DNA binding.
   
 
 0.568
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.