STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG9890LD46465p; Nucleic acid binding. (452 aa)    
Predicted Functional Partners:
Orc2
Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
 
 0.843
CG6470
GH25257p; Nucleic acid binding.
      
 0.834
Orc3
Origin recognition complex subunit 3 (Orc3) encodes a subunit of the origin recognition complex. It is involved in DNA replication initiation and border follicle cell migration regulation.
   
 
 0.815
e(y)2
Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...]
   
 
 0.778
thoc5
THO complex subunit 5; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC5 family.
   
 
 0.744
Gcn5
Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis.
   
 
 0.741
trus
Toys are us.
   
 
 0.676
CG6340
GH25653p.
    
 
 0.671
xmas
Protein xmas-2; Xmas (xmas) encodes encodes a hydrophilic protein that is involved in spermatogenesis, oogenesis and embryogenesis.
   
  
 0.652
Zpr1
LD37736p; Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation.
   
  
 0.641
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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