STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PaskPAS kinase; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation; negative regulation of glycogen biosynthetic process. (985 aa)    
Predicted Functional Partners:
UGP
UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response.
   
 
 0.655
kcc
Kazachoc, isoform G; Kazachoc (kcc) encodes a potassium:chloride symporter that contributes to seizure susceptibility.
   
 
 0.654
CG4041
LD42868p; Rab GTPase binding; GTPase activator activity; ATP binding. It is involved in the biological process described with: activation of GTPase activity; Golgi organization; protein phosphorylation; regulation of GTPase activity; intracellular protein transport.
      
 0.650
sds22
GH07711p; It is involved in the biological process described with: negative regulation of cell population proliferation; establishment or maintenance of polarity of larval imaginal disc epithelium; establishment or maintenance of polarity of follicular epithelium.
    
 
 0.629
Ncc69
Sodium chloride cotransporter 69 (Ncc69) encodes a member of the SLC12 family of Na[+]/K[+]/2Cl[-] cotransporters (NKCC).
    
 
 0.577
coil
Coilin; Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Required for Cajal body formation. Belongs to the coilin family.
   
 
 0.521
Sec71
Secretory 71; Small GTPase binding; ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of neuron remodeling; positive regulation of endocytosis; Golgi to plasma membrane protein transport; regulation of ARF protein signal transduction.
    
 
 0.497
ClC-c
Chloride channel-c (ClC-c) encodes an intracellular chloride transporter that is involved in endosomal lumen acidification.
      
 0.493
Ptp99A
Protein tyrosine phosphatase 99A (Ptp99A) encodes a transmembrane receptor tyrosine phosphatase. Its single mutants have no known phenotypes, but Ptp99A synergizes with Ptp69D to increase the penetrance of the Ptp69D motor axon defects. Ptp99A mutations also suppress the 'bypass' motor axon phenotype produced by Lar mutations; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
    
 
 0.466
CG8878
BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation.
    
 
 0.460
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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