STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Rap2lRas-associated protein 2-like, isoform A; GTP binding; GDP binding; GTPase activity. It is involved in the biological process described with: germ-line stem cell population maintenance; negative regulation of cell migration; Rap protein signal transduction. (182 aa)    
Predicted Functional Partners:
Epac
Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion.
    
 
 0.889
Rgl
Ral guanine nucleotide dissociation stimulator-like, isoform E; Ral guanyl-nucleotide exchange factor activity; Ras GTPase binding. It is involved in the biological process described with: regulation of Ras protein signal transduction; small GTPase mediated signal transduction; activation of GTPase activity.
    
 
 0.798
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.750
PDZ-GEF
PDZ domain-containing guanine nucleotide exchange factor (PDZ-GEF) encodes a guanine nucleotide exchange factor for the product of Rap1. The product of PDZ-GEF contributes to ventral furrow formation, border cell migration, macrophage migration, epithelial migration and morphogenesis, eye development, ovary development, spermathecae formation, germline stem cell maintenance in the testis, adherens junction formation, and anchorage of stem cells to niche.
   
 
 0.743
C3G
Guanine nucleotide-releasing factor 2; C3G guanyl-nucleotide exchange factor (C3G) is expressed in the developing embryonic muscles and its product plays a role in body wall muscle development during larval stages.
    
 
 0.652
RapGAP1
Rap GTPase activating protein 1 (RapGAP1) encodes a small G protein that mediates the activation of ERK signaling via the kinase encoded by tor.
    
 
 0.647
eIF1A
Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition.
  
  
 0.629
Nf1
Neurofibromin 1 (Nf1) encodes a protein that functions as a GTPase activating protein for the products of Ras85D and Ras64B in the larval and adult nervous system. Loss of Nf1 results in excess Ras-Raf-ERK signaling and to a non-cell-autonomous cAMP/PKA signaling defect. The product of Nf1 contributes to postembryonic growth, learning/memory, and circadian rhythm.
    
 
 0.606
Raf
Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
   
 
 0.575
loco
Regulator of G-protein signaling loco; Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunit Galphai. Confers GAP activity on G(o) alpha subunit Galphao and G(i) alpha subunit Galphai. Involved in the dorsal- ventral axis formation of the egg. Acts as a G-protein signaling for glial [...]
    
 
 0.571
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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