STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHDPPutative homeodomain protein; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated (220 aa)    
Predicted Functional Partners:
Tbh
Tyramine beta hydroxylase (Tbh) is a monooxygenase and the key limiting enzyme in octopamine synthesis. Tbh regulates egg laying, positive associative olfactory learning and memory, aggression, flight initiation and maintenance, locomotor activity and attraction to ethanol containing food sources; Belongs to the copper type II ascorbate-dependent monooxygenase family
   
  
 0.727
Kaz1-ORFB
KAZ1-type serine protease inhibitor-like protein type epsilon; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: regulation of proteolysis
      
 0.671
hth
Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...]
      
 0.658
tup
Tailup, isoform A; Tailup is a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development
      
 0.644
ple
Pale is a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development
   
  
 0.619
Vps45
Vacuolar protein sorting 45 is an SM protein that is activated by Rab5 and binds Rbsn-5 to control entry of endocytosed cargo into the early endosome; Belongs to the STXBP/unc-18/SEC1 family
    
   0.613
l(1)sc
Achaete-scute complex protein T3; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system
    
 
 0.567
CG4328
FI06571p; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; zinc ion binding. It is involved in the biological process described with: phagocytosis; regulation of transcription, DNA-templated; dendrite morphogenesis
      
 0.556
POSH
Plenty of SH3s; Ubiquitin-protein transferase activity; protein kinase binding; zinc ion binding; receptor signaling complex scaffold activity; ubiquitin protein ligase activity
    
   0.546
Hand
FI14601p; Sequence-specific DNA binding transcription factor activity; protein dimerization activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. It is involved in the biological process described with: negative regulation of apoptotic process; regulation of transcription, DNA-templated; dendrite morphogenesis; embryonic heart tube development; hemopoiesis; larval heart development; positive regulation of transcription elongation from RNA polymerase II promoter
    
 
 0.512
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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