STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
shuInactive peptidyl-prolyl cis-trans isomerase shutdown; Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations. (455 aa)    
Predicted Functional Partners:
vret
Protein vreteno; Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues.
   
  
 0.979
SoYb
Sister of Yb (SoYb) encodes a putative RNA helicase in the TDRD12 family. It has an essential role in primary piRNA biogenesis in ovarian somatic cells and is predicted to also have a role in germline piRNA biogenesis.
   
 
 0.962
armi
Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...]
   
 
 0.962
Gasz
GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface.
   
 
 0.911
zuc
Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...]
  
  
 0.893
aub
Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...]
   
  
 0.886
krimp
FI20010p1; Metal ion binding. It is involved in the biological process described with: oocyte dorsal/ventral axis specification; negative regulation of oskar mRNA translation; oocyte karyosome formation.
  
 
 0.834
piwi
Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...]
   
 
 0.832
BoYb
Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells.
   
 
 0.830
spn-E
Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]
  
 
 0.794
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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