node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BoYb | Gasz | FBpp0078210 | FBpp0087866 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | 0.681 |
BoYb | SoYb | FBpp0078210 | FBpp0292885 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Sister of Yb (SoYb) encodes a putative RNA helicase in the TDRD12 family. It has an essential role in primary piRNA biogenesis in ovarian somatic cells and is predicted to also have a role in germline piRNA biogenesis. | 0.453 |
BoYb | armi | FBpp0078210 | FBpp0301575 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...] | 0.810 |
BoYb | aub | FBpp0078210 | FBpp0079754 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...] | 0.777 |
BoYb | krimp | FBpp0078210 | FBpp0086333 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | FI20010p1; Metal ion binding. It is involved in the biological process described with: oocyte dorsal/ventral axis specification; negative regulation of oskar mRNA translation; oocyte karyosome formation. | 0.850 |
BoYb | piwi | FBpp0078210 | FBpp0079755 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] | 0.753 |
BoYb | shu | FBpp0078210 | FBpp0072146 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Inactive peptidyl-prolyl cis-trans isomerase shutdown; Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations. | 0.830 |
BoYb | spn-E | FBpp0078210 | FBpp0082637 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] | 0.888 |
BoYb | vret | FBpp0078210 | FBpp0083716 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Protein vreteno; Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues. | 0.961 |
BoYb | zuc | FBpp0078210 | FBpp0079900 | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | 0.822 |
Gasz | BoYb | FBpp0087866 | FBpp0078210 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Brother of Yb (BoYb) encodes a putative RNA helicase in the TDRD12 family and is predicted to have a role in piRNA biogenesis, specifically in ovarian germline cells. | 0.681 |
Gasz | SoYb | FBpp0087866 | FBpp0292885 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Sister of Yb (SoYb) encodes a putative RNA helicase in the TDRD12 family. It has an essential role in primary piRNA biogenesis in ovarian somatic cells and is predicted to also have a role in germline piRNA biogenesis. | 0.803 |
Gasz | armi | FBpp0087866 | FBpp0301575 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Probable RNA helicase armi; Probable RNA helicase required for axial polarization of the oocyte during early and mid oogenesis. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Required both for the translational control of oskar (osk) mRNA and c [...] | 0.964 |
Gasz | aub | FBpp0087866 | FBpp0079754 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...] | 0.848 |
Gasz | krimp | FBpp0087866 | FBpp0086333 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | FI20010p1; Metal ion binding. It is involved in the biological process described with: oocyte dorsal/ventral axis specification; negative regulation of oskar mRNA translation; oocyte karyosome formation. | 0.729 |
Gasz | piwi | FBpp0087866 | FBpp0079755 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] | 0.761 |
Gasz | shu | FBpp0087866 | FBpp0072146 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Inactive peptidyl-prolyl cis-trans isomerase shutdown; Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations. | 0.911 |
Gasz | spn-E | FBpp0087866 | FBpp0082637 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] | 0.874 |
Gasz | vret | FBpp0087866 | FBpp0083716 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Protein vreteno; Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues. | 0.867 |
Gasz | zuc | FBpp0087866 | FBpp0079900 | GH09064p; Gasz (Gasz) encodes an essential factor for primary piRNA biogenesis. It is predicted to stimulate cleavage of piRNA precursors by the endonuclease encoded by zuc via the recruitment of piRNA precursors and biogenesis factors to the mitochondrial surface. | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | 0.959 |