STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mthl10Probable G-protein coupled receptor Mth-like 10; G protein-coupled receptor activity. It is involved in the biological process described with: determination of adult lifespan; response to starvation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; Belongs to the G-protein coupled receptor 2 family. Mth subfamily. (585 aa)    
Predicted Functional Partners:
Gbp1
Growth-blocking peptide 1 (Gbp1) encodes a cytokine that regulates the humoral immune response.
   
 
 0.719
Lcp9
Larval cuticle protein 9; Component of the cuticle of the larva.
    
 
 0.670
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
   
 
 0.498
GMF
Glia maturation factor (GMF) encodes a protein belonging to the ADF-H domain family of proteins, which promote dissambly of actin networks. It specifically binds to and promotes disassembly of Arp2/3-nucleated lamellipodial actin networks. It plays a role in promoting protrusion dynamics during cell migration.
      
 0.436
hec
Hector, isoform A; Hector (hec) encodes a G-protein coupled receptor involved in male courtship behavior.
      
 0.430
CG15556
FI21270p1; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
      
 0.424
Ptpmeg
Protein tyrosine phosphatase Meg (Ptpmeg) encodes a tyrosine phosphatase that interacts with the product of Eps-15. It negatively regulates border cell migration during oogenesis. It also inhibits the EGFR/Ras/mitogen-activated protein kinase signaling pathway during wing morphogenesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
    
 
 0.419
NKCC
Sodium:potassium:chloride symporter activity; potassium:chloride symporter activity; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; amino acid transmembrane transporter activity.
    
 
 0.405
CG13995
Neuropeptide receptor activity; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway.
    
 
 0.403
CG11318
RE14222p; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
   
  
 0.403
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.