node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Capr | Usp10 | FBpp0311792 | FBpp0305465 | Caprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs. | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 0.770 |
Capr | rin | FBpp0311792 | FBpp0312064 | Caprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs. | Rasputin, isoform B; Rasputin (rin) encodes an RNA-binding protein that regulates gene expression. It is involved in eye development and the dorsal/ventral axis specification of the ovary. | 0.959 |
RpII215 | Su(Tpl) | FBpp0073387 | FBpp0310656 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | RNA polymerase II elongation factor Ell; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III ; Belongs to the ELL/occludin family. | 0.693 |
RpII215 | Usp10 | FBpp0073387 | FBpp0305465 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 0.716 |
RpII215 | rin | FBpp0073387 | FBpp0312064 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | Rasputin, isoform B; Rasputin (rin) encodes an RNA-binding protein that regulates gene expression. It is involved in eye development and the dorsal/ventral axis specification of the ovary. | 0.459 |
Rpn11 | Usp10 | FBpp0078664 | FBpp0305465 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 0.620 |
Rpn11 | Usp5 | FBpp0078664 | FBpp0072976 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. | 0.802 |
Rpn11 | calypso | FBpp0078664 | FBpp0086383 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | Ubiquitin carboxyl-terminal hydrolase calypso; Polycomb group (PcG) protein. Catalytic component of the PR- DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys- 48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C12 family. BAP1 subfamily. | 0.948 |
Rpn11 | eIF3f1 | FBpp0078664 | FBpp0078532 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | Eukaryotic translation initiation factor 3 subunit F-1; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. | 0.673 |
Secp43 | Usp10 | FBpp0077144 | FBpp0305465 | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 0.878 |
Secp43 | rin | FBpp0077144 | FBpp0312064 | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. | Rasputin, isoform B; Rasputin (rin) encodes an RNA-binding protein that regulates gene expression. It is involved in eye development and the dorsal/ventral axis specification of the ovary. | 0.869 |
Su(Tpl) | RpII215 | FBpp0310656 | FBpp0073387 | RNA polymerase II elongation factor Ell; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III ; Belongs to the ELL/occludin family. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.693 |
Su(Tpl) | Usp10 | FBpp0310656 | FBpp0305465 | RNA polymerase II elongation factor Ell; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III ; Belongs to the ELL/occludin family. | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 0.621 |
Usp10 | Capr | FBpp0305465 | FBpp0311792 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | Caprin (Capr) encodes an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs. | 0.770 |
Usp10 | RpII215 | FBpp0305465 | FBpp0073387 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.716 |
Usp10 | Rpn11 | FBpp0305465 | FBpp0078664 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | 0.620 |
Usp10 | Secp43 | FBpp0305465 | FBpp0077144 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | RE72132p; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection. | 0.878 |
Usp10 | Su(Tpl) | FBpp0305465 | FBpp0310656 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | RNA polymerase II elongation factor Ell; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III ; Belongs to the ELL/occludin family. | 0.621 |
Usp10 | Usp16-45 | FBpp0305465 | FBpp0309404 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | 0.645 |
Usp10 | Usp5 | FBpp0305465 | FBpp0072976 | Thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of Notch signaling pathway; Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. | 0.663 |