STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hng3Hinge3, isoform A; Basal RNA polymerase II transcription machinery binding; DNA binding; transcription coactivator activity; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (333 aa)    
Predicted Functional Partners:
CG11382
EG:BACR42I17.10 protein.
      
 0.836
CG11226
AT16729p.
      
 0.670
U4-U6-60K
U4-U6 small nuclear riboprotein factor 60K; U4 snRNA binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
  
 0.604
HmgZ
High mobility group protein Z; Transcription factor binding; DNA binding, bending.
      
 0.495
CG4553
FI11059p.
      
 0.461
Taf5
Transcription initiation factor TFIID subunit 5; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery; Belongs to the WD repeat TAF5 family.
   
  
 0.457
mamo
Maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production.
   
  
 0.437
HmgD
High mobility group protein D; Binds preferentially single-stranded DNA and unwinds double- stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.
   
  
 0.432
sqz
Zinc finger protein squeeze; Transcription factor involved in neuronal fate specification. First required in embryonic CNS development to define the number of cells that express apterous (ap) in the ap thoracic cluster of interneurons. Later on, it plays a central role in the combinatorial code of transcription factors that specifies the fate of the Tv neuron in the ap cluster by participating in the transcription regulation of FMRFa in Tv cells. Also required for projection neuron dendritic targeting.
      
 0.430
bru3
Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression.
      
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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