Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Abl | CG30456 | FBpp0303166 | FBpp0271844 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Uncharacterized protein, isoform B. | 0.400 |
| Abl | Mtl | FBpp0303166 | FBpp0084562 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | 0.548 |
| Abl | Rac1 | FBpp0303166 | FBpp0304252 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | 0.693 |
| Abl | Rac2 | FBpp0303166 | FBpp0305023 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Ras-related protein Rac2; Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes. | 0.627 |
| Abl | trio | FBpp0303166 | FBpp0072540 | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. | 0.915 |
| CG17760 | CG30456 | FBpp0110121 | FBpp0271844 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Uncharacterized protein, isoform B. | 0.763 |
| CG17760 | trio | FBpp0110121 | FBpp0072540 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. | 0.857 |
| CG30456 | Abl | FBpp0271844 | FBpp0303166 | Uncharacterized protein, isoform B. | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | 0.400 |
| CG30456 | CG17760 | FBpp0271844 | FBpp0110121 | Uncharacterized protein, isoform B. | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. | 0.763 |
| CG30456 | Rac1 | FBpp0271844 | FBpp0304252 | Uncharacterized protein, isoform B. | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | 0.721 |
| CG30456 | Rac2 | FBpp0271844 | FBpp0305023 | Uncharacterized protein, isoform B. | Ras-related protein Rac2; Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes. | 0.448 |
| CG30456 | trio | FBpp0271844 | FBpp0072540 | Uncharacterized protein, isoform B. | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. | 0.801 |
| Mtl | Abl | FBpp0084562 | FBpp0303166 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | 0.548 |
| Mtl | Rac1 | FBpp0084562 | FBpp0304252 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | 0.478 |
| Mtl | Unc-115a | FBpp0084562 | FBpp0289791 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Uncoordinated 115a, isoform B; Uncoordinated 115a (Unc-115a) encodes a protein involved in axon pathfinding in the visual system and the CNS. | 0.546 |
| Mtl | Unc-115b | FBpp0084562 | FBpp0081572 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Uncoordinated 115b, isoform C; Actin filament binding. It is involved in the biological process described with: lamellipodium assembly. | 0.546 |
| Mtl | strat | FBpp0084562 | FBpp0079221 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side o [...] | 0.923 |
| Mtl | trio | FBpp0084562 | FBpp0072540 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. | 0.869 |
| Mtl | unc-5 | FBpp0084562 | FBpp0309017 | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. | 0.481 |
| Rac1 | Abl | FBpp0304252 | FBpp0303166 | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] | Tyrosine-protein kinase Abl; Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways. | 0.693 |
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