STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BgbBig brother (Bgb) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bro in embryonic segmentation; Belongs to the CBF-beta family. (253 aa)    
Predicted Functional Partners:
run
Segmentation protein Runt; Runt (run) encodes an alpha-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It contributes to axon guidance, dendrite morphogenesis and germ-band extension.
    
 0.982
lz
Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...]
    
 0.906
Cul5
FI20194p1; Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction; Belongs to the cullin family.
    
 
 0.898
EloC
Elongin C (EloC) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto.
   
 
 0.891
EloB
Elongin B (EloB) encodes an essential protein for development that participates in the control of wing cell identity. EloB, EloC and EloA encode for subunits of the Elongin complex, which interacts in vivo with the chromatin factor encoded by corto.
   
 
 0.863
Art1
Protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; histone methyltransferase activity (H4-R3 specific); histone methyltransferase activity. It is involved in the biological process described with: histone methylation; histone H4-R3 methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
   
 
  0.807
RunxA
Runt related A, isoform D; DNA-binding transcription factor activity; ATP binding; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; dendrite morphogenesis.
    
 0.746
RunxB
Runt related B; ATP binding; DNA-binding transcription factor activity; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
    
 0.746
Psc
Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...]
   
 0.676
CG3708
Uncharacterized protein; Chromatin binding; histone binding. It is involved in the biological process described with: cell differentiation; nucleosome assembly.
      
 0.660
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (74%) [HD]