node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCAS2 | CG32655 | FBpp0084638 | FBpp0073466 | LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling. | MIP14002p. | 0.994 |
BCAS2 | Vta1 | FBpp0084638 | FBpp0072691 | LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
CAP | Pu | FBpp0307676 | FBpp0071507 | CAP, isoform X; CAP (CAP) encodes a protein that localizes to focal adhesions and associates with proteins that regulate cytoskeletal organization, including the product of Vinc. It regulates the assembly and function of two actin-rich structures: the larval muscle attachment site, and the fly chordotonal organs in the larval body wall and in the adult Johnston's organ. | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | 0.994 |
CAP | Vta1 | FBpp0307676 | FBpp0072691 | CAP, isoform X; CAP (CAP) encodes a protein that localizes to focal adhesions and associates with proteins that regulate cytoskeletal organization, including the product of Vinc. It regulates the assembly and function of two actin-rich structures: the larval muscle attachment site, and the fly chordotonal organs in the larval body wall and in the adult Johnston's organ. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
CG32655 | BCAS2 | FBpp0073466 | FBpp0084638 | MIP14002p. | LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling. | 0.994 |
CG32655 | Vta1 | FBpp0073466 | FBpp0072691 | MIP14002p. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
Chmp1 | Ist1 | FBpp0311533 | FBpp0076658 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | 0.999 |
Chmp1 | Vps2 | FBpp0311533 | FBpp0084340 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. | 0.999 |
Chmp1 | Vps4 | FBpp0311533 | FBpp0309628 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. | 0.998 |
Chmp1 | Vps60 | FBpp0311533 | FBpp0305334 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] | 0.996 |
Chmp1 | Vta1 | FBpp0311533 | FBpp0072691 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.999 |
Ist1 | Chmp1 | FBpp0076658 | FBpp0311533 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | 0.999 |
Ist1 | Vps2 | FBpp0076658 | FBpp0084340 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. | 0.984 |
Ist1 | Vps4 | FBpp0076658 | FBpp0309628 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. | 0.989 |
Ist1 | Vps60 | FBpp0076658 | FBpp0305334 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] | 0.997 |
Ist1 | Vta1 | FBpp0076658 | FBpp0072691 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
Pu | CAP | FBpp0071507 | FBpp0307676 | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | CAP, isoform X; CAP (CAP) encodes a protein that localizes to focal adhesions and associates with proteins that regulate cytoskeletal organization, including the product of Vinc. It regulates the assembly and function of two actin-rich structures: the larval muscle attachment site, and the fly chordotonal organs in the larval body wall and in the adult Johnston's organ. | 0.994 |
Pu | Rtnl1 | FBpp0071507 | FBpp0290753 | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.994 |
Pu | Vta1 | FBpp0071507 | FBpp0072691 | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
Rtnl1 | Pu | FBpp0290753 | FBpp0071507 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | 0.994 |