STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7967Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway (316 aa)    
Predicted Functional Partners:
Vps60
Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...]
   
 0.999
Vps4
Vacuolar protein sorting 4, isoform A; ATP binding; ATPase activity. It is involved in the biological process described with: phagocytosis; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; negative regulation of growth of symbiont in host; negative regulation of Notch signaling pathway; establishment or maintenance of epithelial cell apical/basal polarity; actin cytoskeleton organization; autophagic vacuole fusion; intracellular protein transport
   
 0.997
Chmp1
Charged multivesicular body protein 1, isoform A; It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; vacuolar transport; negative regulation of epidermal growth factor receptor signaling pathway; Belongs to the SNF7 family
   
 0.997
Vps2
Vacuolar protein sorting 2; It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; endosomal transport; negative regulation of Notch signaling pathway; vacuolar transport; negative regulation of epidermal growth factor receptor signaling pathway; regulation of Notch signaling pathway; Belongs to the SNF7 family
   
 0.996
Vps24
Vacuolar protein sorting 24 is an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding; Belongs to the SNF7 family
   
 0.995
Vps20
Vacuolar protein sorting 20 (Vps20) is a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, Vps20 is also involved in abscission following cytokinesis; Belongs to the SNF7 family
   
 
 0.994
CAP
CAP, isoform Q; CAP
    
 
 0.992
Pu
GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation
    
   0.989
CG32655
annotation not available
    
   0.989
BCAS2
LD24242p; It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA processing
    
   0.989
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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