STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
Jafrac2Thioredoxin peroxidase 2 (Jafrac2) encodes an atypical 2-Cys peroxiredoxin that regulates hydrogen peroxide levels and participates in the formation of disulfide bonds during oxidative protein folding. (242 aa)    
Predicted Functional Partners:
Diap1
Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...]
    
 
 0.842
Prx5
Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis.
   
 
 0.838
CG6762
Putative sulfiredoxin; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (By similarity); Belongs to the sulfiredoxin family.
   
 
 0.817
Trx-2
Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.
  
 
 0.682
Diap2
Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]
    
   0.649
CG9314
CG9314 protein; Catalase activity; heme binding. It is involved in the biological process described with: response to oxidative stress; hydrogen peroxide catabolic process; response to hydrogen peroxide; oxidation-reduction process.
  
 
 0.632
Cat
Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species.
  
 
 0.626
Coprox
Oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity).
  
 
 0.620
PHGPx
PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.
   
 
 0.613
CG15116
Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.
   
 
 0.613
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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