Zyx102.44 isoform; Zyxin (Zyx) encodes an actin cytoskeleton regulator found at cell-matrix junctions and cell-cell adherens junctions. Its roles include mechanotransduction and regulation of the Hippo signaling pathway.

Parvin, isoform A; Parvin (parvin) encodes a Calponin-homology protein that, together with the products of Ilk and stck, reinforces integrin-matrix adhesion at muscle attachment sites in the developing embryo. The product of parvin contributes to cell adhesion and actin cytoskeleton organisation in muscles, wing and eye epithelial cells.

Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...]

Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and alpha-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function; Belongs to the vinculin/alpha-catenin family.

LIM domain-containing protein; Steamer duck (stck) encodes PINCH, an adapter protein that directly binds and forms a complex with the products of Ilk and ics. PINCH is required for integrin-dependent cell adhesion and signaling.

Paxillin, isoform F; Paxillin (Pax) encodes an adaptor protein that is generally associated with integrins. It is not required for most integrin-mediated adhesion or migration events, but is required for viability beyond pupal stages. It controls the size of some muscles by regulating the rate of cell fusion.

Rhea, isoform B; Rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells.

Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...]

Kank, isoform D; Kank (Kank) encodes a microtubule plus-end binding protein.