STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chd64Transgelin; Chd64 (Chd64) encodes a protein involved in the juvenile hormone mediated signaling pathway; Belongs to the calponin family. (188 aa)    
Predicted Functional Partners:
Fkbp39
39 kDa FK506-binding nuclear protein; PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development.
   
 
 0.933
EcR
Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis.
    
 
 0.768
jbug
Jitterbug, isoform N; Jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction.
   
  
 0.606
CG5984
Uncharacterized protein; Actin binding. It is involved in the biological process described with: actin cytoskeleton organization; cell differentiation.
      
 0.596
Fim
Fimbrin, isoform D; Fimbrin (Fim) encodes an actin-binding protein involved in chromosome segregation.
   
 
 0.584
CG17349
GH16267p; Hsp90 protein binding; chaperone binding; Hsp70 protein binding; G protein-coupled receptor binding. It is involved in the biological process described with: negative regulation of cell death.
    
 
 0.579
CG15120
Chaperone binding; ubiquitin protein ligase binding; Hsp90 protein binding; Hsp70 protein binding. It is involved in the biological process described with: negative regulation of cell death.
    
 
 0.579
chic
Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance.
   
 
 0.576
Bug22
Cilia- and flagella-associated protein 20; Basal body up regulated gene 22 (Bug22) encodes a ciliary protein involved in cilium organization and assembly. It contributes to multiple processes during spermatogenesis including tubulin polyglycylation, axoneme assembly, sperm individualization and motility. It also contributes to locomotion, dendrite morphogenesis and neuron and muscle development; Belongs to the CFAP20 family.
    
 
 0.571
CG17118
DUF667 domain-containing protein; It is involved in the biological process described with: positive regulation of cell motility; cilium assembly; regulation of cilium beat frequency involved in ciliary motility.
    
 
 0.571
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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