STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FaaFumarylacetoacetase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; homogentisate catabolic process; tyrosine catabolic process. (417 aa)    
Predicted Functional Partners:
GstZ2
Probable maleylacetoacetate isomerase 2; Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). Belongs to the GST superfamily. Zeta family.
 
 
 0.979
hgo
Homogentisate 1,2-dioxygenase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; oxidation-reduction process; cellular amino acid metabolic process; tyrosine metabolic process.
 
  
 0.964
CG5793
Uncharacterized protein, isoform B; Acetylpyruvate hydrolase activity; hydrolase activity.
   
 
 0.960
GstZ1
Probable maleylacetoacetate isomerase 1; Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).
  
 
 0.955
Hpd
4-hydroxyphenylpyruvate dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; tyrosine catabolic process.
 
  
 0.910
SdhA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
  
 
 0.841
SdhAL
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  
 
 0.840
SdhC
Succinate dehydrogenase, subunit C (SdhC) encodes a protein involved in mitochondrial electron transport and oxidative stress response.
  
 
 0.840
Fum1
Fumarase 1, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; tricarboxylic acid cycle.
  
 0.832
Fum2
Fumarase 2; Fumarate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; fumarate metabolic process.
  
 0.829
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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