Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Blm | CG10336 | FBpp0081910 | FBpp0271702 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | 0.863 |
| Blm | Claspin | FBpp0081910 | FBpp0312156 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. | 0.455 |
| Blm | RPA2 | FBpp0081910 | FBpp0080967 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.984 |
| Blm | RPA3 | FBpp0081910 | FBpp0310183 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. | 0.993 |
| Blm | RpA-70 | FBpp0081910 | FBpp0081356 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.997 |
| Blm | Top3alpha | FBpp0081910 | FBpp0080787 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils [...] | 0.999 |
| Blm | Top3beta | FBpp0081910 | FBpp0309042 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA topoisomerase 3-beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...] | 0.990 |
| Blm | mus302 | FBpp0081910 | FBpp0075105 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | RE72625p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. | 0.514 |
| Blm | timeout | FBpp0081910 | FBpp0082180 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Timeout (timeout) encodes a role in the maintenance of chromosome integrity and in the light synchronization of the adult circadian clock. | 0.790 |
| CG10336 | Blm | FBpp0271702 | FBpp0081910 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | 0.863 |
| CG10336 | Claspin | FBpp0271702 | FBpp0312156 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. | 0.920 |
| CG10336 | RPA2 | FBpp0271702 | FBpp0080967 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.918 |
| CG10336 | RPA3 | FBpp0271702 | FBpp0310183 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. | 0.961 |
| CG10336 | RpA-70 | FBpp0271702 | FBpp0081356 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.979 |
| CG10336 | Sld5 | FBpp0271702 | FBpp0084348 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Sld5 (Sld5) encodes a subunit of the Cdc45/Mcm2-7/GINS (CMG) complex, which is associated with an ATP-dependent DNA helicase function and is involved in the regulation of the mitotic G1/S transition. | 0.993 |
| CG10336 | mus302 | FBpp0271702 | FBpp0075105 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | RE72625p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. | 0.558 |
| CG10336 | timeout | FBpp0271702 | FBpp0082180 | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | Timeout (timeout) encodes a role in the maintenance of chromosome integrity and in the light synchronization of the adult circadian clock. | 0.998 |
| Claspin | Blm | FBpp0312156 | FBpp0081910 | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | 0.455 |
| Claspin | CG10336 | FBpp0312156 | FBpp0271702 | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. | Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity). | 0.920 |
| Claspin | RPA2 | FBpp0312156 | FBpp0080967 | Claspin; Required for checkpoint signaling in response to DNA replication stress; either resulting from normal embryogenesis or induced by the DNA synthesis inhibitor hydroxyurea (HU). It is not required for the G2 arrest resulting from DNA double strand breaks induced by ionizing irradiation (IR). Necessary for the timely phosphorylation of Cdk1 at the mid-blastula transition. May have a minor role in maintaining genomic stability in mitotic cells. Belongs to the claspin family. | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.807 |
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