STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPA3Replication protein A3, isoform A; DNA binding. It is involved in the biological process described with: DNA recombination; neuronal stem cell maintenance; DNA replication; DNA repair; neurogenesis (112 aa)    
Predicted Functional Partners:
RpA-70
Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage
   
 0.996
RPA2
Replication protein A2, isoform A; DNA binding. It is involved in the biological process described with: DNA recombination; DNA repair; DNA-dependent DNA replication; neurogenesis
   
 0.994
dUTPase
Deoxyuridine triphosphatase, isoform A; dUTP diphosphatase activity. It is involved in the biological process described with: dUTP metabolic process
   
    0.904
Blm
Bloom syndrome helicase plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination
     
 0.858
Top3alpha
DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...]
     
 0.801
Top3beta
DNA topoisomerase 3-beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...]
     
  0.800
hdm
Hold'em is predicted to be a single-strand DNA binding protein based on the presence of three Oligosaccharide-Binding (OB) folds. It is involved in making meiotic crossovers and in some DNA repair process
    
 
 0.775
SmD1
Small ribonucleoprotein particle protein SmD1 (SmD1) is an RNA binding protein that forms a heterodimeric sub-complex with SmD2. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing
   
    0.670
CG3165
CG3165, isoform A; Nucleic acid binding
    
   0.611
CG31460
annotation not available
   
    0.608
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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