STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wispPoly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa)    
Predicted Functional Partners:
osk
Maternal effect protein oskar; Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nos RNA and staufen protein at the posterior pole.
   
 
 0.923
orb
Oo18 RNA-binding protein (orb) encodes a RNA-binding protein required for the formation of the egg chamber and establishment of polarity during oogenesis. It is involved in mRNA polyadenylation and the regulation of osk mRNA translation.
   
 
 0.910
bcd
Homeotic protein bicoid; Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.
   
 
 0.902
mtrm
Protein matrimony; Polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females. Holds heterochromatically paired homologs together from the end of pachytene until metaphase I. Haploinsufficient locus for homologous achiasmate segregation and may be required for the maintenance of heterochromatic pairings.
   
 
 0.889
gnu
CG5272 protein; Giant nuclei (gnu) encodes a regulatory subunit of the PNG kinase complex, which regulates the levels of the protein encoded by CycB. Members of this complex are required maternally for the normal nuclear divisions of the syncytial embryo.
   
 
 0.884
swa
Protein swallow; Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis.
   
  
 0.850
otu
Protein ovarian tumor locus; Essential for female fertility; germ cell division and differentiation.
   
   0.840
yl
Putative vitellogenin receptor; Involved in uptake of vitellogenin by endocytosis.
   
    0.839
Pxt
Chorion peroxidase; Peroxinectin-like (Pxt) encodes a cycloxygenase-like enzyme that contributes to the synthesis of prostaglandins. Prostaglandins activate G protein-coupled receptor signaling. Its roles include oogenesis, sperm individualization, morphogenesis, nucleolar structure, temporal control of gene expression, and regulation of gene amplification; Belongs to the peroxidase family. XPO subfamily.
   
    0.834
CG11674
LD24340p.
   
    0.791
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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