STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fwFurrowed, isoform A; Furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. (1174 aa)    
Predicted Functional Partners:
CG2258
LD35927p; Myosin binding.
      
 0.895
PGAP1
GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. Belongs to the GPI inositol-deacylase family.
      
 0.838
hec
Hector, isoform A; Hector (hec) encodes a G-protein coupled receptor involved in male courtship behavior.
      
 0.836
CG7896
LD30178p.
   
    0.654
wus
Wurst, isoform A; Wurst (wus) encodes a transmembrane protein essential for clathrin-mediated endocytosis. It recruits the product of Hsc70-4 and clathrin to the apical cell membrane of epithelial cells. The endocytosis mediated by the product of wus is required for size determination and lumen clearance of the airways.
      
 0.625
mei-P26
Meiotic P26, isoform F; Meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis.
      
 0.602
CG9095
Uncharacterized protein, isoform B; Carbohydrate binding.
  
 
0.570
Tep3
Thioester-containing protein 3 (Tep3) encodes a protein involved in the defense response to Gram-positive bacteria.
   
  0.536
Cad96Cb
Cadherin 96Cb, isoform D; Calcium ion binding. It is involved in the biological process described with: homophilic cell adhesion via plasma membrane adhesion molecules; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell-cell adhesion mediated by cadherin; open tracheal system development.
  
 
 0.532
Mcr
Macroglobulin complement-related (Mcr) encodes a transmembrane protein of the conserved thioester-containing protein (TEP) superfamily including macroglobulins and complement proteins. It is a core component of septate junctions, which provide an essential paracellular barrier to epithelia.
   
  0.518
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.