STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG1640AT04676p; Pyridoxal phosphate binding; L-alanine:2-oxoglutarate aminotransferase activity. It is involved in the biological process described with: biosynthetic process. (575 aa)    
Predicted Functional Partners:
Got2
Aspartate aminotransferase; Glutamate oxaloacetate transaminase 2 (Got2) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis, which in turn regulates postsynaptic receptor field size.
   
 0.996
Spat
Serine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism.
  
 0.972
Got1
Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis.
   
 0.971
Gdh
Glutamate dehydrogenase, mitochondrial; Glutamate dehydrogenase (Gdh) encodes a glutamate dehydrogenase involved glutamate metabolism.
  
 
 0.949
bb8
Big bubble 8 (bb8) encodes a glutamate dehydrogenase involved in the development of the spermatid mitochondria; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.942
CG11241
IP18034p; Pyridoxal phosphate binding; alanine-glyoxylate transaminase activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.934
Idh
Isocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes.
  
 
 0.908
Nc73EF
Neural conserved at 73EF, isoform I; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle.
   
 
 0.872
SdhA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.
   
 
 0.870
Fum1
Fumarase 1, isoform A; Fumarate hydratase activity. It is involved in the biological process described with: fumarate metabolic process; tricarboxylic acid cycle.
   
 0.866
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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