STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG1764GM09012p; Amino acid binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; dimethylargininase activity. It is involved in the biological process described with: positive regulation of nitric oxide biosynthetic process; citrulline metabolic process; arginine metabolic process. (268 aa)    
Predicted Functional Partners:
CG11241
IP18034p; Pyridoxal phosphate binding; alanine-glyoxylate transaminase activity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.664
Iyd
Iodotyrosine deiodinase, isoform A.
      
 0.622
t
Tan, isoform A; Tan (t) encodes a hydrolase involved in both the conversion of N-beta-alanyldopamine to dopamine in the cuticle and central nervous system, and the conversion of beta-alanylhistamine (carcinine) to histamine in the retina. It functions in vision, cuticular melanization, and neurotransmitter recycling.
  
  
 0.597
Oat
Ornithine aminotransferase, mitochondrial; Ornithine-oxo-acid transaminase activity; identical protein binding; pyridoxal phosphate binding. It is involved in the biological process described with: arginine catabolic process to proline via ornithine; ornithine metabolic process; arginine catabolic process to glutamate.
  
  
 0.577
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.551
arg
Arginase (arg) encodes an enzyme that converts arginine into ornithine. Lack of arg produces a developmental embryonic delay.
     
 0.545
Tspo
Translocator protein (Tspo) encodes a protein localized in the outer mitochondrial membrane that is thought to be involved in various pathways, including steroid and heme biosynthesis, apoptosis, protein import, cell proliferation and differentiation and also has been proposed to participate in the formation of the mitochondrial permeability transition pore.
   
  
 0.516
CG11403
EG:33C11.2 protein; DNA helicase activity; DNA binding; helicase activity; ATP binding. It is involved in the biological process described with: establishment of sister chromatid cohesion; nucleobase-containing compound metabolic process; DNA duplex unwinding.
   
  
 0.507
CG4853
FI05912p; Ras guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of Ras protein signal transduction; mushroom body development.
   
    0.493
Pdss2
Decaprenyl diphosphate synthase subunit 2, isoform A; Prenyltransferase activity; trans-hexaprenyltranstransferase activity. It is involved in the biological process described with: isoprenoid biosynthetic process; ubiquinone biosynthetic process; Belongs to the FPP/GGPP synthase family.
   
    0.471
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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