node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG2931 | dgt3 | FBpp0078402 | FBpp0271922 | RE50009p; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome. | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | 0.940 |
CG2931 | jub | FBpp0078402 | FBpp0073665 | RE50009p; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome. | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.778 |
alpha-Cat | crb | FBpp0070037 | FBpp0293268 | Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | 0.618 |
alpha-Cat | jub | FBpp0070037 | FBpp0073665 | Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.776 |
alpha-Cat | shg | FBpp0070037 | FBpp0071475 | Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. | DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] | 0.998 |
alpha-Cat | yki | FBpp0070037 | FBpp0402906 | Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] | 0.477 |
alpha-Catr | jub | FBpp0303286 | FBpp0073665 | Alpha-catenin related, isoform C; Actin filament binding. It is involved in the biological process described with: cell adhesion; Rho protein signal transduction. | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.611 |
alpha-Catr | shg | FBpp0303286 | FBpp0071475 | Alpha-catenin related, isoform C; Actin filament binding. It is involved in the biological process described with: cell adhesion; Rho protein signal transduction. | DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] | 0.468 |
crb | alpha-Cat | FBpp0293268 | FBpp0070037 | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | Catenin alpha; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. | 0.618 |
crb | hpo | FBpp0293268 | FBpp0304253 | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | 0.790 |
crb | jub | FBpp0293268 | FBpp0073665 | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.673 |
crb | shg | FBpp0293268 | FBpp0071475 | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] | 0.907 |
crb | yki | FBpp0293268 | FBpp0402906 | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] | 0.844 |
dgt3 | CG2931 | FBpp0271922 | FBpp0078402 | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | RE50009p; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of mRNA splicing, via spliceosome. | 0.940 |
dgt3 | jub | FBpp0271922 | FBpp0073665 | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.796 |
hpo | crb | FBpp0304253 | FBpp0293268 | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] | 0.790 |
hpo | jub | FBpp0304253 | FBpp0073665 | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. | 0.675 |
hpo | sav | FBpp0304253 | FBpp0083749 | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | Scaffold protein salvador; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the [...] | 0.999 |
hpo | wts | FBpp0304253 | FBpp0085082 | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | Serine/threonine-protein kinase Warts; Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activi [...] | 0.993 |
hpo | yki | FBpp0304253 | FBpp0402906 | Serine/threonine-protein kinase hippo; Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the act [...] | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] | 0.998 |