node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG7718 | CLS | FBpp0083097 | FBpp0084303 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | 0.988 |
CG7718 | Cds | FBpp0083097 | FBpp0312164 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | 0.962 |
CG7718 | Pis | FBpp0083097 | FBpp0073874 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.966 |
CG9391 | Pis | FBpp0296988 | FBpp0073874 | Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate dephosphorylation; inositol metabolic process; signal transduction. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.930 |
CLS | CG7718 | FBpp0084303 | FBpp0083097 | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.988 |
CLS | Cds | FBpp0084303 | FBpp0312164 | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | 0.965 |
CLS | Pis | FBpp0084303 | FBpp0073874 | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.950 |
Cds | CG7718 | FBpp0312164 | FBpp0083097 | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. | 0.962 |
Cds | CLS | FBpp0312164 | FBpp0084303 | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. | 0.965 |
Cds | Pi4KIIIalpha | FBpp0312164 | FBpp0303977 | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | 0.432 |
Cds | Pis | FBpp0312164 | FBpp0073874 | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.988 |
Pi3K59F | Pi4KIIIalpha | FBpp0071973 | FBpp0303977 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | 0.931 |
Pi3K59F | Pis | FBpp0071973 | FBpp0073874 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.940 |
Pi3K59F | Pten | FBpp0071973 | FBpp0289789 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. | 0.968 |
Pi3K59F | Sac1 | FBpp0071973 | FBpp0072546 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance. | 0.947 |
Pi3K59F | fwd | FBpp0071973 | FBpp0423146 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | Four wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family. | 0.928 |
Pi3K59F | mtm | FBpp0071973 | FBpp0311457 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | Myotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. | 0.975 |
Pi4KIIIalpha | Cds | FBpp0303977 | FBpp0312164 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] | 0.432 |
Pi4KIIIalpha | Pi3K59F | FBpp0303977 | FBpp0071973 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.931 |
Pi4KIIIalpha | Pis | FBpp0303977 | FBpp0073874 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] | 0.965 |