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Chc protein (fruit fly) - STRING interaction network
"Chc" - Clathrin heavy chain forms part of the clathrin complex, which is the major component of coated vesicles in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ChcClathrin heavy chain forms part of the clathrin complex, which is the major component of coated vesicles (1678 aa)    
Predicted Functional Partners:
aux
Auxilin, isoform A; Protein kinase activity; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with- synaptic vesicle uncoating; protein phosphorylation; compound eye morphogenesis; sperm individualization; Notch signaling pathway (1165 aa)
     
  0.999
Clc
Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (219 aa)
     
  0.999
lqf
Liquid facets, isoform A; It is involved in the biological process described with- positive regulation of Notch signaling pathway; synaptic vesicle endocytosis; autophagy; endocytosis; storage protein import into fat body; negative regulation of cardioblast cell fate specification; regulation of Notch signaling pathway; neurotransmitter secretion (831 aa)
     
  0.998
lap
Phosphatidylinositol-binding clathrin assembly protein LAP; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction; Belongs to the PICALM/SNAP91 family (788 aa)
     
  0.998
Eps-15
Epidermal growth factor receptor pathway substrate clone 15, isoform A; Calcium ion binding. It is involved in the biological process described with- regulation of synaptic growth at neuromuscular junction; receptor-mediated endocytosis; negative regulation of Notch signaling pathway; vesicle-mediated transport; synaptic vesicle endocytosis; neurotransmitter secretion (1253 aa)
     
  0.997
shi
Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family (896 aa)
     
  0.997
AP-2alpha
AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP-2alpha is a subunit of the plasma membrane adapter (952 aa)
     
  0.997
AP-2mu
Adaptor Protein complex 2, mu subunit is a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization (437 aa)
     
  0.996
Hip1
Huntingtin interacting protein 1, isoform A; Phospholipid binding; actin binding. It is involved in the biological process described with- cytoskeleton organization (1124 aa)
     
  0.994
AP-1-2beta
AP complex subunit beta; Protein transporter activity. It is involved in the biological process described with- vesicle coating; synaptic vesicle coating; vesicle-mediated transport; compound eye development; intracellular protein transport; neurotransmitter secretion (921 aa)
     
  0.992
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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