STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NufipNufip is an adaptor protein for the assembly of RiboNucleo-Particles (RNPs) such as the small nuclear RNP U4 (snRNP U4; part of the spliceosome) and the mRNPs encoding seleno-proteins. Nufip is necessary for the biogenesis of the small nucleolar RNPs (snoRNPs) (511 aa)    
Predicted Functional Partners:
CG8204
annotation not available
    
 
 0.966
Fmr1
Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression. Required for stability of the central pair of microtubules in the spermatid axoneme. Regulates photoreceptor [...]
    
 
 0.862
Pih1D1
annotation not available
      
 0.798
Prp31
Prp31 is a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development
   
 
 0.797
Nop56
Nucleolar KKE/D repeat protein; It is involved in the biological process described with: neurogenesis
   
 
 0.790
Zfrp8
Zinc finger protein RP-8 (Zfrp8) is a highly conserved protein essential for stem cell maintenance and fast proliferating cells such as cancer cells. Zfrp8 functions in the formation of mRNA ribonucleoprotein (mRNP) complexes. Zfrp8 may regulate the binding of specific mRNPs to the small ribosomal subunit, ultimately controlling their cytoplasmic localization and translation
   
 
 0.774
Capr
Caprin is an RNA-binding translational regulator that is present in cytoplasmic RNA granules (neuronal granules and stress granules). It modulates diverse cellular processes including neuronal function, cell proliferation and differentiation through post-transcriptional regulation of target RNAs
   
  
 0.768
nop5
CG10206-PA; It is involved in the biological process described with: rRNA processing
   
 
 0.758
hoip
NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity)
   
 
 0.743
CG12320
annotation not available
   
  
 0.682
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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