STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tsp74FTetraspanin 74F (236 aa)    
Predicted Functional Partners:
CG14353
annotation not available
      
 0.915
Prestin
FI18412p1; Oxalate transmembrane transporter activity; calcium ion transmembrane transporter activity; formate transmembrane transporter activity; high-affinity sulfate transmembrane transporter activity; sulfate transmembrane transporter activity; inorganic anion exchanger activity; bicarbonate transmembrane transporter activity. It is involved in the biological process described with: bicarbonate transport; calcium ion transmembrane transport; formate transport; oxalate transport; sulfate transport
   
  
 0.854
Atg4a
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy
      
 0.564
Atg4b
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy
      
 0.564
tilB
Protein tilB; Touch insensitive larva B (TilB) is required for the assembly and/or transport to the cilium of axonemal dynein arms. TilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. TilB interacts with Zmynd10, which has a similar distribution and mutant phenotype
      
 0.481
if
Inflated is one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers
    
 
 0.442
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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