Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Egfr | Krn | FBpp0071571 | FBpp0074961 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | 0.978 |
| Egfr | S | FBpp0071571 | FBpp0077658 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. | 0.758 |
| Egfr | esg | FBpp0071571 | FBpp0080293 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Protein escargot; Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ [...] | 0.621 |
| Egfr | rho | FBpp0071571 | FBpp0305409 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. | 0.943 |
| Egfr | ru | FBpp0071571 | FBpp0072574 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Roughoid/rhomboid-3; Roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye; Belongs to the peptidase S54 family. | 0.501 |
| Egfr | upd1 | FBpp0071571 | FBpp0074353 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Unpaired 1 (upd1) encodes a secreted glycoprotein that is able to act at a distance as the primary ligand for the JAK/STAT signaling pathway. Although semi-redundant with upd2 and upd3, upd1 depletion results in embryonic lethality with an atypical gap gene-like segmentation phenotype. | 0.703 |
| Egfr | upd2 | FBpp0071571 | FBpp0423083 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. | 0.580 |
| Egfr | upd3 | FBpp0071571 | FBpp0112376 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. | 0.707 |
| Egfr | vn | FBpp0071571 | FBpp0076790 | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | Vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. | 0.994 |
| Krn | Egfr | FBpp0074961 | FBpp0071571 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | 0.978 |
| Krn | S | FBpp0074961 | FBpp0077658 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. | 0.537 |
| Krn | esg | FBpp0074961 | FBpp0080293 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Protein escargot; Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ [...] | 0.614 |
| Krn | rho | FBpp0074961 | FBpp0305409 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. | 0.818 |
| Krn | ru | FBpp0074961 | FBpp0072574 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Roughoid/rhomboid-3; Roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye; Belongs to the peptidase S54 family. | 0.667 |
| Krn | stet | FBpp0074961 | FBpp0072596 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Stem cell tumor, isoform B; Stem cell tumor (stet) encodes a gonad-specific intra-membrane protease of the rhomboid family that activates ligands of the product of Egfr; Belongs to the peptidase S54 family. | 0.630 |
| Krn | upd1 | FBpp0074961 | FBpp0074353 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Unpaired 1 (upd1) encodes a secreted glycoprotein that is able to act at a distance as the primary ligand for the JAK/STAT signaling pathway. Although semi-redundant with upd2 and upd3, upd1 depletion results in embryonic lethality with an atypical gap gene-like segmentation phenotype. | 0.549 |
| Krn | upd2 | FBpp0074961 | FBpp0423083 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. | 0.676 |
| Krn | upd3 | FBpp0074961 | FBpp0112376 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Unpaired 3 (upd3) encodes a "cytokine" (secreted protein) of the Unpaired family that can bind and activate the JAK-STAT receptor encoded by dome. It is induced in hemocytes or in the intestine upon damage to regulate the repair response in these tissues through JAK-STAT activation. | 0.686 |
| Krn | vn | FBpp0074961 | FBpp0076790 | LD34429p; Keren (Krn) encodes an ligand for the receptor encoded by Egfr that is processed by the products of S and rho. It shows a redundant role with the products of spi in very few tissues. | Vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. | 0.518 |
| S | Egfr | FBpp0077658 | FBpp0071571 | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] | 0.758 |
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