STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
stProtein scarlet; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules. (666 aa)    
Predicted Functional Partners:
w
White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker.
  
 
  
0.634
CG11069
LD11139p; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
   
 
0.583
GPHR
Golgi pH Regulator (GPHR) encodes an anion channel that regulates Golgi luminal pH. It is expressed in both ER and Golgi apparatus and is necessary for proper function of the secretory pathway.
      
 0.513
CG9270
Uncharacterized protein; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
  
 
 0.499
CG7806
LD42916p; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
  
 
 0.483
CG10505
Uncharacterized protein; CG10505 encodes an ABC transporter whose expression is induced by excess copper, zinc, and cadmium. It is a target of the metal-responsive transcription factor encoded by MTF-1.
  
 
 0.437
CG34402
Uncharacterized protein, isoform C.
      
 0.432
CG31875
GEO13032p1; DNA-binding transcription factor activity; transcription factor binding; transcription corepressor activity; transcription regulatory region sequence-specific DNA binding.
      
 0.432
Oatp58Dc
Solute carrier organic anion transporter family member; Organic anion transporting polypeptide 58Dc (Oatp58Dc) encodes a membrane transporter implicated in renal elimination of organic compounds including ouabain and methotrexate. In the perineural glia of the blood brain barrier, the product of Oatp58Dc protects the brain from potentially toxic organic anions in the hemolymph.
   
    0.412
Cln3
Battenin.
   
  
 0.405
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (28%) [HD]