STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pka-C3cAMP-dependent protein kinase catalytic subunit 3; Does not have an essential role in development. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (583 aa)    
Predicted Functional Partners:
Pka-R1
Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol.
 
 
 
 0.986
Pka-R2
cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain.
 
 
 
 0.983
sws
Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family.
    
 
 0.740
Sws1
SWIM domain containing Srs2 interacting protein 1 (Sws1) encodes a protein that is paralog-interacting of the product of spn-A. It is involved in homologous recombination in the repair of double-strand breaks, likely through the product of spn-A regulation.
      
 0.669
Phlpp
Protein phosphatase PHLPP-like protein; Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.
      
 0.610
CG12069
UT01108p; cAMP-dependent protein kinase activity; ATP binding. It is involved in the biological process described with: protein kinase A signaling; protein phosphorylation.
  
0.601
CG8252
Protein kinase A regulatory subunit binding.
   
 
  0.541
DCX-EMAP
Echinoderm microtubule-associated protein-like CG42247; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
    
 
 0.536
CG8641
MIP08469p; GTPase activity; GTP binding. It is involved in the biological process described with: signal transduction.
   
 
 0.527
Mos
Mos oncogene (Mos) encodes a kinase that activates the MAPK cascade during oogenesis; Belongs to the protein kinase superfamily.
  
 
 
 0.524
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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