STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MsrAEcdysone-induced protein 28/29kD (Eip71CD) encodes a methionine-S-sulfoxide reductase involved in the response to oxidative stress. It contributes to determination of adult lifespan and neuron projection. (261 aa)    
Predicted Functional Partners:
SelR
Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.
 
 
 0.990
Eip55E
Ecdysone-induced protein 55E (Eip55E) encodes a protein involved in glutathione biosynthesis.
  
 
 0.894
CG3719
EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis.
   
 
 0.733
CG8993
GEO01508p1; Disulfide oxidoreductase activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis; glycerol ether metabolic process.
  
 
 0.720
CG8517
GEO08746p1; Protein disulfide oxidoreductase activity; disulfide oxidoreductase activity. It is involved in the biological process described with: glycerol ether metabolic process; cell redox homeostasis.
   
 
 0.720
CG13473
GEO12009p1; Protein-disulfide reductase activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; disulfide oxidoreductase activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis.
  
 
 0.718
TrxT
Thioredoxin-T; Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Its tissue specificity suggests a regulatory role in the germline.
  
 
 0.704
Trx-2
Thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1.
  
 
 0.700
Grx1
Glutaredoxin 1 (Grx1) encodes a protein involved in copper ion homeostasis.
  
 
 0.692
Grx1t
Glutaredoxin 1, testis-specific; Electron transfer activity; protein disulfide oxidoreductase activity; glutathione-disulfide reductase activity. It is involved in the biological process described with: cellular response to oxidative stress; cell redox homeostasis.
  
 
 0.686
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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