node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG4704 | HGTX | FBpp0308283 | FBpp0075463 | Uncharacterized protein, isoform A; Calcium ion binding. It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport. | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | 0.609 |
Fer1 | HGTX | FBpp0306731 | FBpp0075463 | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | 0.646 |
Fer1 | Oli | FBpp0306731 | FBpp0080539 | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | Olig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated. | 0.570 |
Fer1 | Sox100B | FBpp0306731 | FBpp0085097 | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad. | 0.408 |
Fer1 | tup | FBpp0306731 | FBpp0080661 | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development. | 0.424 |
Fer1 | vnd | FBpp0306731 | FBpp0070105 | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages. | 0.435 |
HGTX | CG4704 | FBpp0075463 | FBpp0308283 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Uncharacterized protein, isoform A; Calcium ion binding. It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport. | 0.609 |
HGTX | Fer1 | FBpp0075463 | FBpp0306731 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | 48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N. | 0.646 |
HGTX | HHEX | FBpp0075463 | FBpp0083439 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Hematopoietically expressed homeobox (HHEX) encodes a transcription factor involved in response to sucrose. | 0.579 |
HGTX | Lim3 | FBpp0075463 | FBpp0302972 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity. | 0.714 |
HGTX | Oli | FBpp0075463 | FBpp0080539 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Olig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated. | 0.712 |
HGTX | Sox100B | FBpp0075463 | FBpp0085097 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad. | 0.554 |
HGTX | gro | FBpp0075463 | FBpp0089115 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. | 0.619 |
HGTX | mid | FBpp0075463 | FBpp0078726 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Midline, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription corepressor binding. | 0.566 |
HGTX | tup | FBpp0075463 | FBpp0080661 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development. | 0.653 |
HGTX | vnd | FBpp0075463 | FBpp0070105 | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | Homeobox protein vnd; Ventral nervous system defective (vnd) encodes a Nk2-class homeodomain transcription factor that acts in a context-dependent manner as an activator or repressor. It has roles in neuroectoderm patterning, formation and specification of ventral neuroblasts and proper development of their cell lineages. | 0.678 |
HHEX | HGTX | FBpp0083439 | FBpp0075463 | Hematopoietically expressed homeobox (HHEX) encodes a transcription factor involved in response to sucrose. | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | 0.579 |
HHEX | mid | FBpp0083439 | FBpp0078726 | Hematopoietically expressed homeobox (HHEX) encodes a transcription factor involved in response to sucrose. | Midline, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription corepressor binding. | 0.432 |
Lim3 | HGTX | FBpp0302972 | FBpp0075463 | Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity. | GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation. | 0.714 |
Lim3 | Oli | FBpp0302972 | FBpp0080539 | Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity. | Olig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated. | 0.498 |