STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lmx1aLIM homeobox transcription factor 1 alpha, isoform B; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: neuron differentiation; positive regulation of transcription by RNA polymerase II. (640 aa)    
Predicted Functional Partners:
CG31690
Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
   
  
 0.710
sv
Shaven, isoform A; Shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye.
   
 
 0.676
beat-IIIa
Beaten path IIIa, isoform D; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules.
      
 0.664
FMRFa
Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation.
   
 
 0.626
Ddc
Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family.
      
 0.612
Chi
Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance.
    
 
 0.610
CG31760
Probable G-protein coupled receptor CG31760; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
   
    0.586
Oatp26F
Solute carrier organic anion transporter family member; Transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; active transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; sodium-independent organic anion transport; organic substance transport.
   
   0.574
klg
LD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment.
   
    0.573
Corin
Corin, isoform B; Serine-type endopeptidase activity; scavenger receptor activity. It is involved in the biological process described with: proteolysis.
    
 
 0.567
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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