| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG6565 | Start1 | FBpp0312088 | FBpp0293591 | LD05321p; Lipid binding. | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | 0.643 |
| CG6565 | cert | FBpp0312088 | FBpp0076440 | LD05321p; Lipid binding. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.624 |
| CG6565 | cv-c | FBpp0312088 | FBpp0111542 | LD05321p; Lipid binding. | Crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis. | 0.621 |
| CG9945 | cert | FBpp0085539 | FBpp0076440 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.542 |
| Cerk | Sk2 | FBpp0078446 | FBpp0072854 | Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration. | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | 0.560 |
| Cerk | cert | FBpp0078446 | FBpp0076440 | Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.570 |
| Pi4KIIIalpha | Vap33 | FBpp0303977 | FBpp0309607 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. | 0.729 |
| Pi4KIIIalpha | cert | FBpp0303977 | FBpp0076440 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.542 |
| Pi4KIIIalpha | fwd | FBpp0303977 | FBpp0423146 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | Four wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family. | 0.979 |
| Pi4KIIIalpha | rdgB | FBpp0303977 | FBpp0304106 | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.575 |
| Sk2 | Cerk | FBpp0072854 | FBpp0078446 | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration. | 0.560 |
| Sk2 | cert | FBpp0072854 | FBpp0076440 | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.581 |
| Sk2 | rdgB | FBpp0072854 | FBpp0304106 | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | Retinal degeneration B (rdgB) encodes a member of the Class IIA Phosphatidylinositol transfer protein (PITP) family. It supports multiple biochemical functions involving lipid transfer during G-protein coupled phospholipase C activation. | 0.435 |
| Start1 | CG6565 | FBpp0293591 | FBpp0312088 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | LD05321p; Lipid binding. | 0.643 |
| Start1 | Vap33 | FBpp0293591 | FBpp0309607 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. | 0.813 |
| Start1 | cert | FBpp0293591 | FBpp0076440 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.727 |
| Start1 | cv-c | FBpp0293591 | FBpp0111542 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | Crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis. | 0.608 |
| Vap33 | Pi4KIIIalpha | FBpp0309607 | FBpp0303977 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. | Phosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. | 0.729 |
| Vap33 | Start1 | FBpp0309607 | FBpp0293591 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. | 0.813 |
| Vap33 | cert | FBpp0309607 | FBpp0076440 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.778 |